Porphyromonas gingivalis Gingipains-Mediated Degradation of Plasminogen Activator Inhibitor-1 Leads to Delayed Wound Healing Responses in Human Endothelial Cells

• Main Authors: Li-Ting Song (Author), Hiroyuki Tada (Author), Takashi Nishioka (Author), Eiji Nemoto (Author), Takahisa Imamura (Author), Jan Potempa (Author), Chang-Yi Li (Author), Kenji Matsushita (Author), Shunji Sugawara (Author)
• Format: Book
• Published: Karger Publishers, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor, is constitutively produced by endothelial cells and plays a vital role in maintaining vascular homeostasis. Chronic periodontitis is an inflammatory disease characterized by bleeding of periodontal tissues that support the tooth...