Effects of CREB1 gene silencing on cognitive dysfunction by mediating PKA-CREB signaling pathway in mice with vascular dementia

• Main Authors: Xin-Rui Han (Author), Xin Wen (Author), Yong-Jian Wang (Author), Shan Wang (Author), Min Shen (Author), Zi-Feng Zhang (Author), Shao-Hua Fan (Author), Qun Shan (Author), Liang Wang (Author), Meng-Qiu Li (Author), Bin Hu (Author), Chun-Hui Sun (Author), Dong-Mei Wu (Author), Jun Lu (Author), Yuan-Lin Zheng (Author)
• Format: Book
• Published: BMC, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background As a form of dementia primarily affecting the elderly, vascular dementia (VD) is characterized by changes in the supply of blood to the brain, resulting in cognitive impairment. The aim of the present study was to explore the effects involved with cyclic adenosine monophosphate (...