B-1 cell-mediated modulation of M1 macrophage profile ameliorates microbicidal functions and disrupt the evasion mechanisms of Encephalitozoon cuniculi.

• Main Authors: Adriano Pereira (Author), Anuska Marcelino Alvares-Saraiva (Author), Fabiana Toshie de Camargo Konno (Author), Diva Denelle Spadacci-Morena (Author), Elizabeth Cristina Perez (Author), Mario Mariano (Author), Maria Anete Lallo (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Here, we have investigated the possible effect of B-1 cells on the activity of peritoneal macrophages in E. cuniculi infection. In the presence of B-1 cells, peritoneal macrophages had an M1 profile with showed increased phagocytic capacity and index, associated with the intense microbicidal activit...