Antiproliferative activity and p53 upregulation effects of chalcones on human breast cancer cells

• Main Authors: Mariana Bastos dos Santos (Author), Daiane Bertholin Anselmo (Author), Jéssica Gisleine de Oliveira (Author), Bruna V. Jardim-Perassi (Author), Diego Alves Monteiro (Author), Gabriel Silva (Author), Eleni Gomes (Author), Ana Lucia Fachin (Author), Mozart Marins (Author), Débora Aparecida Pires de Campos Zuccari (Author), Luis Octavio Regasini (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chalcones are valuable structures for drug discovery due to their broad bioactivity spectrum. In this study, we evaluated 20 synthetic chalcones against estrogen-receptor-positive breast cancer cells (MCF-7 line) and triple-negative breast cancer (TNBC) cells (MDA-MB-231 line). Antiproliferative scr...