Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening.

• Main Authors: Maha-Hamadien Abdulla (Author), Debbie S Ruelas (Author), Brian Wolff (Author), June Snedecor (Author), Kee-Chong Lim (Author), Fengyun Xu (Author), Adam R Renslo (Author), Janice Williams (Author), James H McKerrow (Author), Conor R Caffrey (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Praziquantel (PZQ) is the only widely available drug to treat schistosomiasis. Given the potential for drug resistance, it is prudent to search for novel therapeutics. Identification of anti-schistosomal chemicals has traditionally relied on phenotypic (whole organism)...