An engineered interleukin‐11 decoy cytokine inhibits receptor signaling and proliferation in lung adenocarcinoma

• Main Authors: Brianna J. McIntosh (Author), Griffin G. Hartmann (Author), Sean A. Yamada‐Hunter (Author), Phillip Liu (Author), Camille F. Williams (Author), Julien Sage (Author), Jennifer R. Cochran (Author)
• Format: Book
• Published: Wiley, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The cytokine interleukin (IL)‐11 has been shown to play a role in promoting fibrosis and cancer, including lung adenocarcinoma, garnering interest as an attractive target for therapeutic intervention. We used combinatorial methods to engineer an IL‐11 variant that binds with higher affinity...