Enhancing regeneration after acute kidney injury by promoting cellular dedifferentiation in zebrafish

• Main Authors: Lauren Brilli Skvarca (Author), Hwa In Han (Author), Eugenel B. Espiritu (Author), Maria A. Missinato (Author), Elizabeth R. Rochon (Author), Michael D. McDaniels (Author), Abha S. Bais (Author), Beth L. Roman (Author), Joshua S. Waxman (Author), Simon C. Watkins (Author), Alan J. Davidson (Author), Michael Tsang (Author), Neil A. Hukriede (Author)
• Format: Book
• Published: The Company of Biologists, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute kidney injury (AKI) is a serious disorder for which there are limited treatment options. Following injury, native nephrons display limited regenerative capabilities, relying on the dedifferentiation and proliferation of renal tubular epithelial cells (RTECs) that survive the insult. Previously...