MiRNA/mRNA network topology in hepatitis virus B-related liver cirrhosis reveals miR-20a-5p/340-5p as hubs initiating fibrosis

• Main Authors: Heng Yao (Author), Peng Li (Author), Jiaojiao Xin (Author), Xi Liang (Author), Jing Jiang (Author), Dongyan Shi (Author), Jiang Li (Author), Hozeifa Mohamed Hassan (Author), Xin Chen (Author), Jun Li (Author)
• Format: Book
• Published: BMC, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The pathophysiology of hepatitis B-related liver cirrhosis (HBV-LC) remains unclear. This study aimed to explore the disease mechanisms using topological analysis of the miRNA/mRNA network. Methods Paired miRNA/mRNA sequencing was performed with thirty-three peripheral blood mono...