Does HLA explain the high incidence of childhood-onset type 1 diabetes in the Canary Islands? The role of Asp57 DQB1 molecules

• Main Authors: Yeray Nóvoa-Medina (Author), Itahisa Marcelino-Rodriguez (Author), Nicolás M. Suárez (Author), Marta Barreiro-Bautista (Author), Eva Rivas-García (Author), Santiago Sánchez-Alonso (Author), Gema González-Martínez (Author), Sofía Quinteiro-González (Author), Ángela Domínguez (Author), María Cabrera (Author), Sara López (Author), Svetlana Pavlovic (Author), Carlos Flores (Author), Gran Canarian Diabetes and Obesity Research Group (Author), Ana M. Wägner (Author)
• Format: Book
• Published: BMC, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The Canary Islands inhabitants, a recently admixed population with significant North African genetic influence, has the highest incidence of childhood-onset type 1 diabetes (T1D) in Spain and one of the highest in Europe. HLA accounts for half of the genetic risk of T1D. Aims To characteriz...