Does HLA explain the high incidence of childhood-onset type 1 diabetes in the Canary Islands? The role of Asp57 DQB1 molecules

• Glavni autori: Yeray Nóvoa-Medina (Autor), Itahisa Marcelino-Rodriguez (Autor), Nicolás M. Suárez (Autor), Marta Barreiro-Bautista (Autor), Eva Rivas-García (Autor), Santiago Sánchez-Alonso (Autor), Gema González-Martínez (Autor), Sofía Quinteiro-González (Autor), Ángela Domínguez (Autor), María Cabrera (Autor), Sara López (Autor), Svetlana Pavlovic (Autor), Carlos Flores (Autor), Gran Canarian Diabetes and Obesity Research Group (Autor), Ana M. Wägner (Autor)
• Format: Knjiga
• Izdano: BMC, 2024-09-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract The Canary Islands inhabitants, a recently admixed population with significant North African genetic influence, has the highest incidence of childhood-onset type 1 diabetes (T1D) in Spain and one of the highest in Europe. HLA accounts for half of the genetic risk of T1D. Aims To characteriz...