Substance P-modified human serum albumin nanoparticles loaded with paclitaxel for targeted therapy of glioma

• Main Authors: Chunhui Ruan (Author), Lisha Liu (Author), Yifei Lu (Author), Yu Zhang (Author), Xi He (Author), Xinli Chen (Author), Yujie Zhang (Author), Qinjun Chen (Author), Qin Guo (Author), Tao Sun (Author), Chen Jiang (Author)
• Format: Book
• Published: Elsevier, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The blood-brain barrier (BBB) and the poor ability of many drugs to cross that barrier greatly limits the efficacy of chemotherapies for glioblastoma multiforme (GBM). The present study exploits albumin as drug delivery vehicle to promote the chemotherapeutic efficacy of paclitaxel (PTX) by improvin...