Novel Survivin Inhibitor YM155 elicits Cytotoxicity in Glioblastoma Cell Lines with Normal or Deficiency DNA-Dependent Protein Kinase Activity

• Autori principali: Pei Chun Lai (Autore), Shu Huey Chen (Autore), Shang Hsien Yang (Autore), Chuan Chu Cheng (Autore), Ted H. Chiu (Autore), Yen Ta Huang (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2012-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Pediatric glioblastoma is a malignant disease with an extremely poor clinical outcome. Patients usually suffer from resistance to radiation therapy, so targeted drug treatment may be a new possibility for glioblastoma therapy. Survivin is also overexpressed in glioblastoma. YM155, a novel small-mole...