Endothelin-1 Production by Normal Human Cultured Keratinocytes and its Regulation

• Main Authors: Hajime Inoue (Author), Nagaoki Wakisaka (Author), Nobuhiro Tane (Author), Kazumasa Ando (Author), Emiko Isono (Author), Miwa Yamanaka (Author), Masaki Aihara (Author), Hirotomo Ishida (Author)
• Format: Book
• Published: Hindawi Limited, 1994-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The possibility that cultured keratinocytes produce endothelins were investigated. The results showed that cultured keratinocytes derived from normal human skin produce endothelin-1. Moreover, keratinocyte endothelin-1 production was completely inhibited by the presence of actinomycin D in the mediu...