Time-Dependent Distribution of Hydroxychloroquine in Cynomolgus Macaques Using Population Pharmacokinetic Modeling Method

• Main Authors: Qi Liu (Author), Guofang Bi (Author), Guiying Chen (Author), Xuan Guo (Author), Siqi Tu (Author), Xiaolin Tong (Author), Man Xu (Author), Mengjie Liu (Author), Bei Wang (Author), Hongliang Jiang (Author), Jufeng Wang (Author), Haiyan Li (Author), Kun Wang (Author), Dongyang Liu (Author), Chunli Song (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To evaluate the biodistribution of hydroxychloroquine (HCQ) in cynomolgus macaques and receive dynamic quantitative relationship between plasma, blood, and lung tissue concentration using the population pharmacokinetic modeling method, seventeen cynomolgus macaques were divided into six groups accor...