An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery

• Main Authors: Lee F. Willoughby (Author), Tanja Schlosser (Author), Samuel A. Manning (Author), John P. Parisot (Author), Ian P. Street (Author), Helena E. Richardson (Author), Patrick O. Humbert (Author), Anthony M. Brumby (Author)
• Format: Book
• Published: The Company of Biologists, 2013-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Anti-cancer drug development involves enormous expenditure and risk. For rapid and economical identification of novel, bioavailable anti-tumour chemicals, the use of appropriate in vivo tumour models suitable for large-scale screening is key. Using a Drosophila Ras-driven tumour model, we de...