Remdesivir and Cyclosporine Synergistically Inhibit the Human Coronaviruses OC43 and SARS-CoV-2

• Main Authors: Hsing-Yu Hsu (Author), Cheng-Wei Yang (Author), Yue-Zhi Lee (Author), Yi-Ling Lin (Author), Sui-Yuan Chang (Author), Ruey-Bing Yang (Author), Jian-Jong Liang (Author), Tai-Ling Chao (Author), Chun-Che Liao (Author), Han-Chieh Kao (Author), Szu-Huei Wu (Author), Jang-Yang Chang (Author), Huey-Kang Sytwu (Author), Chiung-Tong Chen (Author), Shiow-Ju Lee (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Remdesivir, a prodrug targeting RNA-dependent-RNA-polymerase, and cyclosporine, a calcineurin inhibitor, individually exerted inhibitory activity against human coronavirus OC43 (HCoV-OC43) in HCT-8 and MRC-5 cells at EC50 values of 96 ± 34 ∼ 85 ± 23 nM and 2,920 ± 364 ∼ 4,419 ± 490 nM, respectively....