Do Genetic Polymorphisms Affect Fetal Hemoglobin (HbF) Levels in Patients With Sickle Cell Anemia Treated With Hydroxyurea? A Systematic Review and Pathway Analysis

• Hauptverfasser: Rahyssa Rodrigues Sales (Verfasst von), Bárbara Lisboa Nogueira (Verfasst von), Jéssica Abdo Gonçalves Tosatti (Verfasst von), Karina Braga Gomes (Verfasst von), Marcelo Rizzatti Luizon (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Schlagworte: article
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Hydroxyurea has long been used for the treatment of sickle cell anemia (SCA), and its clinical effectiveness is related to the induction of fetal hemoglobin (HbF), a major modifier of SCA phenotypes. However, there is substantial variability in response to hydroxyurea among patients with SCA. While...