The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration

• Main Authors: Wennan Lu (Author), Néstor M. Gómez (Author), Jason C. Lim (Author), Sonia Guha (Author), Ann O'Brien-Jenkins (Author), Erin E. Coffey (Author), Keith E. Campagno (Author), Stuart A. McCaughey (Author), Alan M. Laties (Author), Leif G. Carlsson (Author), Claire H. Mitchell (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The accumulation of partially degraded lipid waste in lysosomal-related organelles may contribute to pathology in many aging diseases. The presence of these lipofuscin granules is particularly evident in the autofluorescent lysosome-associated organelles of the retinal pigmented epithelial (RPE) cel...