Discovery and Characterization of a Dual-Function Peptide Derived from Bitter Gourd Seed Protein Using Two Orthogonal Bioassay-Guided Fractionations Coupled with In Silico Analysis

• Principais autores: Wei-Ting Hung (Autor), Christoper Caesar Yudho Sutopo (Autor), Mei-Li Wu (Autor), Jue-Liang Hsu (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2023-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The hydrolysate of bitter gourd seed protein, digested by the combined gastrointestinal proteases (BGSP-GPs), exhibited the most potent inhibition on angiotensin-I-converting enzyme (ACE) with an IC₅₀ value of 48.1 ± 2.0 µg/mL. Using two independent bioassay-guided fractionati...