Discovery and Characterization of a Dual-Function Peptide Derived from Bitter Gourd Seed Protein Using Two Orthogonal Bioassay-Guided Fractionations Coupled with In Silico Analysis

• Main Authors: Wei-Ting Hung (Author), Christoper Caesar Yudho Sutopo (Author), Mei-Li Wu (Author), Jue-Liang Hsu (Author)
• Format: Knjiga
• Izdano: MDPI AG, 2023-11-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

The hydrolysate of bitter gourd seed protein, digested by the combined gastrointestinal proteases (BGSP-GPs), exhibited the most potent inhibition on angiotensin-I-converting enzyme (ACE) with an IC₅₀ value of 48.1 ± 2.0 µg/mL. Using two independent bioassay-guided fractionati...