Non-Clinical In Vitro Evaluation of Antibiotic Resistance Gene-Free Plasmids Encoding Human or Murine IL-12 Intended for First-in-Human Clinical Study

• Main Authors: Spela Kos (Author), Masa Bosnjak (Author), Tanja Jesenko (Author), Bostjan Markelc (Author), Urska Kamensek (Author), Katarina Znidar (Author), Urska Matkovic (Author), Andrej Rencelj (Author), Gregor Sersa (Author), Rosana Hudej (Author), Aneja Tuljak (Author), Matjaz Peterka (Author), Maja Cemazar (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Interleukin 12 (IL-12) is a key cytokine that mediates antitumor activity of immune cells. To fulfill its clinical potential, the development is focused on localized delivery systems, such as gene electrotransfer, which can provide localized delivery of IL-12 to the tumor microenvironment. Gene elec...