Hepatic GRK2 is dispensable for glucose homeostasis and other key metabolic parameters in mice

• Main Authors: Antwi-Boasiako Oteng (Author), Srinivas Pittala (Author), Andrea Kliewer (Author), Yishu Qiu (Author), Jürgen Wess (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: G-protein-coupled receptor (GPCR) kinases (GRKs) abrogate GPCR signaling by promoting receptor desensitization and internalization. Accumulating evidence suggests that GRK2 represents an important regulator of GPCR-mediated effects on systemic glucose metabolism, obesity, and insulin resi...