Dehydroisohispanolone as a Promising NLRP3 Inhibitor Agent: Bioevaluation and Molecular Docking

• Glavni autori: Laura González-Cofrade (Autor), Irene Cuadrado (Autor), Ángel Amesty (Autor), Ana Estévez-Braun (Autor), Beatriz de las Heras (Autor), Sonsoles Hortelano (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2022-07-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Dehydroisohispanolone (DIH), is a labdane diterpene that has exhibited anti-inflammatory activity via inhibition of NF-κB activation, although its potential effects on inflammasome activation remain unexplored. This study aims to elucidate whether DIH modulates NLR family pyrin domain-containing pro...