Naringin and temozolomide combination suppressed the growth of glioblastoma cells by promoting cell apoptosis: network pharmacology, in-vitro assays and metabolomics based study

• Main Authors: Priya Bisht (Author), Surendra Rajit Prasad (Author), Khushboo Choudhary (Author), Ruchi Pandey (Author), Dande Aishwarya (Author), Vulli Aravind (Author), Peraman Ramalingam (Author), Ravichandiran Velayutham (Author), Nitesh Kumar (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Glioblastoma, which affects a large number of patients every year and has an average overall lifespan of around 14.6 months following diagnosis stands out as the most lethal primary invasive brain tumor. Currently, surgery, radiation, and chemotherapy with temozolomide (TMZ) are the th...