Resuscitation in Paediatric Sepsis Using Metabolic Resuscitation-A Randomized Controlled Pilot Study in the Paediatric Intensive Care Unit (RESPOND PICU): Study Protocol and Analysis Plan

• Main Authors: Luregn J. Schlapbach (Author), Kristen Gibbons (Author), Roberta Ridolfi (Author), Amanda Harley (Author), Michele Cree (Author), Debbie Long (Author), David Buckley (Author), Simon Erickson (Author), Marino Festa (Author), Shane George (Author), Megan King (Author), Puneet Singh (Author), Sainath Raman (Author), Rinaldo Bellomo (Author), The RESPOND PICU study investigators and the Australian New Zealand Intensive Care Society Paediatric Study Group (ANZICS PSG) (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Septic shock remains amongst the leading causes of childhood mortality. Therapeutic options to support children with septic shock refractory to initial resuscitation with fluids and inotropes are limited. Recently, the combination of intravenous hydrocortisone with high dose ascorbic a...