TCR γ4δ1-Engineered αβT Cells Exhibit Effective Antitumor Activity

• Main Authors: Kangxia He (Author), Hongqin You (Author), Yuxia Li (Author), Lianxian Cui (Author), Jianmin Zhang (Author), Wei He (Author)
• Format: Book
• Published: BMC, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract T cell engineering with T cell receptors (TCRs) specific for tumors plays an important role in adoptive T cell transfer (ATC) therapy for cancer. Here, we present a novel strategy to redirect peripheral blood-derived αβT cells against tumors via TCRγ4δ1 gene transduction. The broad-spectrum...