Maternal-Neonatal Raltegravir Population Pharmacokinetics Modeling: Implications for Initial Neonatal Dosing

• Главные авторы: Jos Lommerse (Автор), Diana Clarke (Автор), Thomas Kerbusch (Автор), Henri Merdjan (Автор), Han Witjes (Автор), Hedy Teppler (Автор), Mark Mirochnick (Автор), Edward P. Acosta (Автор), Larissa Wenning (Автор), Sharon Nachman (Автор), Anne Chain (Автор)
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• Опубликовано: Wiley, 2019-09-01T00:00:00Z.
• Предметы: article
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Raltegravir readily crosses the placenta to the fetus with maternal use during pregnancy. After birth, neonatal raltegravir elimination is highly variable and often extremely prolonged, with some neonates demonstrating rising profiles after birth despite removal from the source of extrinsic raltegra...