Mycobactin analogue interacting with siderophore efflux-pump protein: insights from molecular dynamics simulations and whole-cell assays

• Main Authors: Mousumi Shyam (Author), Abhishek Thakur (Author), Caroline Velez (Author), Chris Daniel (Author), Orlando Acevedo (Author), Sanjib Bhakta (Author), Venkatesan Jayaprakash (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionIn response to continued public health emergency of antimicrobial resistance (AMR), a significant key strategy is the discovery of novel mycobacterial efflux-pump inhibitors (EPIs) as potential adjuvants in combination drug therapy. Interest in identifying new chemotypes which could pote...