The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)‐Endoxifen in Breast Cancer

• Main Authors: Jeanine Marie Nardin (Author), Werner Schroth (Author), Thais Abreu Almeida (Author), Thomas Mürdter (Author), Solane Picolotto (Author), Evelyn Castillo Lima Vendramini (Author), Reiner Hoppe (Author), Jenifer Primon Kogin (Author), Diandra Miqueleto (Author), Silvia Dark Robaskievicz deMoraes (Author), Matthias Schwab (Author), Roberto Flavio Pecoits‐Filho (Author), Hiltrud Brauch (Author), José Claudio Casali‐da‐Rocha (Author)
• Format: Book
• Published: Wiley, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tamoxifen efficacy in breast cancer is suspected to depend on adherence and intact drug metabolism. We evaluated the role of adherence behavior and pharmacogenetics on the formation rate of (Z)‐endoxifen. In 192 Brazilian patients, we assessed plasma levels of tamoxifen and its metabolites at 3, 6,...