The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)‐Endoxifen in Breast Cancer

• Автори: Jeanine Marie Nardin (Автор), Werner Schroth (Автор), Thais Abreu Almeida (Автор), Thomas Mürdter (Автор), Solane Picolotto (Автор), Evelyn Castillo Lima Vendramini (Автор), Reiner Hoppe (Автор), Jenifer Primon Kogin (Автор), Diandra Miqueleto (Автор), Silvia Dark Robaskievicz deMoraes (Автор), Matthias Schwab (Автор), Roberto Flavio Pecoits‐Filho (Автор), Hiltrud Brauch (Автор), José Claudio Casali‐da‐Rocha (Автор)
• Формат: Книга
• Опубліковано: Wiley, 2020-03-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Tamoxifen efficacy in breast cancer is suspected to depend on adherence and intact drug metabolism. We evaluated the role of adherence behavior and pharmacogenetics on the formation rate of (Z)‐endoxifen. In 192 Brazilian patients, we assessed plasma levels of tamoxifen and its metabolites at 3, 6,...