Dimeric dipeptide mimetic the 1st loop of nerve growth factor of GK-6, which activates PI3K/AKT and MEK/MAPK/ERK, causes a neuronal type differentiation of PC12 cells

• Main Authors: T. A. Antipova (Author), S. V. Nikolaev (Author), A. V. Revishchin (Author), E. A. Savchenko (Author), G. V. Pavlova (Author), T. A. Gudasheva (Author)
• Format: Book
• Published: LLC "Publisher OKI", 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dimeric dipeptide mimetic 1st loop of NGF GK-6 (10-6M) activating as phosphatidylinozitol 3-kinase/Akt and mitogen-activated protein kinase MEK/MAPK/ERK) signaling cascades causes PC12 cell differentiation into neuron-like cells. At the same time dimeric dipeptide mimetic the 4th loop of NGF GK-2 (1...