In vitro characterization of Trypanosoma cruzi infection dynamics in skeletal and cardiac myotubes models suggests a potential cell-to-cell transmission in mediating cardiac pathology.

• Main Authors: José María Eloy Contreras-Ortiz (Author), Daniel Hernández-Mendoza (Author), Claudia Márquez-Dueñas (Author), Rebeca Manning-Cela (Author), Moisés Santillán (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chagas disease predominantly affects the heart, esophagus, and colon in its chronic phase. However, the precise infection mechanisms of the causal agent Trypanosoma cruzi in these tissue types remain incompletely understood. This study investigated T. cruzi infection dynamics in skeletal (SM) and ca...