Label-free detection of prostaglandin transporter (SLCO2A1) function and inhibition: insights by wound healing and TRACT assays

• Main Authors: Tamara A. M. Mocking (Author), Wieke M. van Oostveen (Author), Jacobus P. D. van Veldhoven (Author), Hugo Minnee (Author), Cynthia M. Fehres (Author), Charles E. Whitehurst (Author), Adriaan P. IJzerman (Author), Laura H. Heitman (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The prostaglandin transporter (PGT, SLCO2A1) mediates transport of prostanoids (a.o. prostaglandin E2 (PGE2)) into cells and thereby promotes their degradation. Overexpression of PGT leads to low extracellular PGE2 levels and has been linked to impaired wound healing of diabetic foot ulcers. Inhibit...