Influence of Oleic Acid on the Rheology and in Vitro Release of Lumiracoxib from Poloxamer Gels

• मुख्य लेखकों: Tailane Sant´Anna Moreira (लेखक), Valéria Pereira de Sousa (लेखक), Maria Bernadete Riemma Pierre (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2010-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract PURPOSE: Transdermal delivery of anti-inflammatory lumiracoxib (LM) could be an interesting strategy to avoid the side effects associated with systemic delivery, but it is ineffective due to the drug poor skin penetration. We have investigated the effects of oleic acid (OA), a lipid penetra...