Chitosan-Based Polyelectrolyte Complexes for Doxorubicin and Zoledronic Acid Combined Therapy to Overcome Multidrug Resistance

• Main Authors: Simona Giarra (Author), Silvia Zappavigna (Author), Virginia Campani (Author), Marianna Abate (Author), Alessia Maria Cossu (Author), Carlo Leonetti (Author), Manuela Porru (Author), Laura Mayol (Author), Michele Caraglia (Author), Giuseppe De Rosa (Author)
• Format: Book
• Published: MDPI AG, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to develop nanovectors co-encapsulating doxorubicin (Doxo) and zoledronic acid (Zol) for a combined therapy against Doxo-resistant tumors. Chitosan (CHI)-based polyelectrolyte complexes (PECs) prepared by ionotropic gelation technique were proposed. The influence of some experimenta...