Chitosan-Based Polyelectrolyte Complexes for Doxorubicin and Zoledronic Acid Combined Therapy to Overcome Multidrug Resistance

• المؤلفون الرئيسيون: Simona Giarra (مؤلف), Silvia Zappavigna (مؤلف), Virginia Campani (مؤلف), Marianna Abate (مؤلف), Alessia Maria Cossu (مؤلف), Carlo Leonetti (مؤلف), Manuela Porru (مؤلف), Laura Mayol (مؤلف), Michele Caraglia (مؤلف), Giuseppe De Rosa (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2018-10-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

This study aimed to develop nanovectors co-encapsulating doxorubicin (Doxo) and zoledronic acid (Zol) for a combined therapy against Doxo-resistant tumors. Chitosan (CHI)-based polyelectrolyte complexes (PECs) prepared by ionotropic gelation technique were proposed. The influence of some experimenta...