Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability

• Main Authors: Li Wang (Author), Matteo Astone (Author), Sk. Kayum Alam (Author), Zhu Zhu (Author), Wuhong Pei (Author), David A. Frank (Author), Shawn M. Burgess (Author), Luke H. Hoeppner (Author)
• Format: Book
• Published: The Company of Biologists, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vascular permeability triggered by inflammation or ischemia promotes edema, exacerbates disease progression and impairs tissue recovery. Vascular endothelial growth factor (VEGF) is a potent inducer of vascular permeability. VEGF plays an integral role in regulating vascular barrier function physiol...