Search for Potent and Selective Aurora A Inhibitors Based on General Ser/Thr Kinase Pharmacophore Model

• Main Authors: Natalya I. Vasilevich (Author), Victor V. Tatarskiy (Author), Elena A. Aksenova (Author), Denis N. Kazyulkin (Author), Ilya I. Afanasyev (Author)
• Formato: Libro
• Publicado: MDPI AG, 2016-04-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Based on the data for compounds known from the literature to be active against various types of Ser/Thr kinases, a general pharmachophore model for these types of kinases was developed. The search for the molecules fitting to this pharmacophore among the ASINEX proprietary library revealed a number...