No QTc Prolongation With Zanubrutinib: Results of Concentration‐QTc Analysis From a Thorough QT Study in Healthy Subjects

• Main Authors: Song Mu (Author), Borje Darpo (Author), Zhiyu Tang (Author), William Novotny (Author), Manal Tawashi (Author), Hongqi Xue (Author), Michael Willett (Author), Leo Lin (Author), Sri Sahasranaman (Author), Ying C. Ou (Author)
• Format: Book
• Published: Wiley, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This thorough QT (TQT) study evaluated the effect of zanubrutinib on electrocardiogram (ECG) parameters by using concentration‐QTc (C‐QTc) analysis as the primary analysis for this study. Part A of the study determined the safety and tolerability of a single supratherapeutic dose of zanubrutinib (48...