Developing a mechanistic translational PK/PD model for a trifunctional NK cell engager to predict the first‐in‐human dose for acute myeloid leukemia

• Päätekijät: Siak‐Leng Choi (Tekijä), Delphine Valente (Tekijä), Angela Virone‐Oddos (Tekijä), Christine Mauriac (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Wiley, 2024-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Abstract Natural killer cell engagers (NKCEs), a treatment that stimulates innate immunity, have lately gained attention owing to their favorable safety profile, and their efficacy. Natural killer (NK) cell activation is driven by immune synapse formation between drugs, NK cells, and tumor cells. Ho...