Specific TLR4 Blocking Effect of a Novel 3,4-Dihydropyrimidinone Derivative

• Glavni autori: Mingqian Zhou (Autor), Yiqi Wang (Autor), Xiaoying Lin (Autor), Jieping Wan (Autor), Chengping Wen (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Background: Toll-like receptor 4 (TLR4) initiates both innate and adaptive immune responses, which plays an important protective role in self-defense mechanisms. Excessive or inappropriate TLR4 activation causes the development of many autoimmune diseases. Dihydropyrimidinone derivatives are medicin...