Specific TLR4 Blocking Effect of a Novel 3,4-Dihydropyrimidinone Derivative

• Egile Nagusiak: Mingqian Zhou (Egilea), Yiqi Wang (Egilea), Xiaoying Lin (Egilea), Jieping Wan (Egilea), Chengping Wen (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Background: Toll-like receptor 4 (TLR4) initiates both innate and adaptive immune responses, which plays an important protective role in self-defense mechanisms. Excessive or inappropriate TLR4 activation causes the development of many autoimmune diseases. Dihydropyrimidinone derivatives are medicin...