Elevated Pressure Changes the Purinergic System of Microglial Cells

• Main Authors: Ana C. Rodrigues-Neves (Author), Inês D. Aires (Author), Joana Vindeirinho (Author), Raquel Boia (Author), Maria H. Madeira (Author), Francisco Q. Gonçalves (Author), Rodrigo A. Cunha (Author), Paulo F. Santos (Author), António F. Ambrósio (Author), Ana R. Santiago (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glaucoma is the second cause of blindness worldwide and is characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy. Increased microglia reactivity is an early event in glaucoma that may precede the loss of RGCs, suggesting that microglia and neuroinflammation are i...