RHBDF1 deficiency suppresses melanoma glycolysis and enhances efficacy of immunotherapy by facilitating glucose-6-phosphate isomerase degradation via TRIM32

• Main Authors: Lei Wang (Author), Yuan-Yuan Song (Author), Yan Wang (Author), Xiu-Xiu Liu (Author), Yi-Lun Yin (Author), Shan Gao (Author), Fan Zhang (Author), Lu-Yuan Li (Author), Zhi-Song Zhang (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Melanoma is a dangerous form of skin cancer, making it important to investigate new mechanisms and approaches to enhance the effectiveness of treatment. Here, we establish a positive correlation between the human rhomboid family-1 (RHBDF1) protein and melanoma malignancy. We demonstrate that the mel...