RHBDF1 deficiency suppresses melanoma glycolysis and enhances efficacy of immunotherapy by facilitating glucose-6-phosphate isomerase degradation via TRIM32

• Hauptverfasser: Lei Wang (VerfasserIn), Yuan-Yuan Song (VerfasserIn), Yan Wang (VerfasserIn), Xiu-Xiu Liu (VerfasserIn), Yi-Lun Yin (VerfasserIn), Shan Gao (VerfasserIn), Fan Zhang (VerfasserIn), Lu-Yuan Li (VerfasserIn), Zhi-Song Zhang (VerfasserIn)
• Format: Buch
• Veröffentlicht: Elsevier, 2023-12-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Melanoma is a dangerous form of skin cancer, making it important to investigate new mechanisms and approaches to enhance the effectiveness of treatment. Here, we establish a positive correlation between the human rhomboid family-1 (RHBDF1) protein and melanoma malignancy. We demonstrate that the mel...