Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis

• Main Authors: Yongsheng Liu (Author), Rezan Güler (Author), Yunqi Liao (Author), Anzhelika Vorobyeva (Author), Olof Widmark (Author), Theodorus J. Meuleman (Author), Anna Koijen (Author), Leendert J. van den Bos (Author), Robert Naasz (Author), Vitalina Bodenko (Author), Anna Orlova (Author), Caroline Ekblad (Author), Vladimir Tolmachev (Author), Fredrik Y. Frejd (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeted molecular radiation therapy is a promising emerging treatment modality in oncology, and peptide synthesis may shorten the time to reach the clinical stage. In this study, we have explored Chemo-Enzymatic Peptide Synthesis, or CEPS, as a new means of producing a therapeutic HER2 targeted Aff...