Cover Image

Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis

Targeted molecular radiation therapy is a promising emerging treatment modality in oncology, and peptide synthesis may shorten the time to reach the clinical stage. In this study, we have explored Chemo-Enzymatic Peptide Synthesis, or CEPS, as a new means of producing a therapeutic HER2 targeted Aff...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yongsheng Liu (Author), Rezan Güler (Author), Yunqi Liao (Author), Anzhelika Vorobyeva (Author), Olof Widmark (Author), Theodorus J. Meuleman (Author), Anna Koijen (Author), Leendert J. van den Bos (Author), Robert Naasz (Author), Vitalina Bodenko (Author), Anna Orlova (Author), Caroline Ekblad (Author), Vladimir Tolmachev (Author), Fredrik Y. Frejd (Author)
Format:	Book
Published:	MDPI AG, 2022-11-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2
by: Tianqi Xu, et al.
Published: (2022)

Preclinical Evaluation of a New Format of <sup>68</sup>Ga- and <sup>111</sup>In-Labeled Affibody Molecule Z<sub>IGF-1R:4551</sub> for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT
by: Yongsheng Liu, et al.
Published: (2022)

Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody<sup>®</sup> Molecules <sup>177</sup>Lu-ABY-271 and <sup>177</sup>Lu-ABY-027: Impact of DOTA Position on ABD Domain
by: Yongsheng Liu, et al.
Published: (2021)

Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule <sup>188</sup>Re-ZHER2:41071
by: Yongsheng Liu, et al.
Published: (2022)

Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution
by: Haozhong Ding, et al.
Published: (2021)

Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation
by: Maryam Oroujeni, et al.
Published: (2024)

Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3
by: Maryam Oroujeni, et al.
Published: (2022)

The Influence of Domain Permutations of an Albumin-Binding Domain-Fused HER2-Targeting Affibody-Based Drug Conjugate on Tumor Cell Proliferation and Therapy Efficacy
by: Wen Yin, et al.
Published: (2021)

Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA
by: Francesco Lechi, et al.
Published: (2024)

Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model
by: Fanny Lundmark, et al.
Published: (2020)

Experimental HER2-Targeted Therapy Using ADAPT6-ABD-mcDM1 in Mice Bearing SKOV3 Ovarian Cancer Xenografts: Efficacy and Selection of Companion Imaging Counterpart
by: Javad Garousi, et al.
Published: (2022)

Evaluating the Therapeutic Efficacy of Mono- and Bivalent Affibody-Based Fusion Proteins Targeting HER3 in a Pancreatic Cancer Xenograft Model
by: Charles Dahlsson Leitao, et al.
Published: (2020)

Imaging using radiolabelled targeted proteins: radioimmunodetection and beyond
by: Javad Garousi, et al.
Published: (2020)

Functional Consequences of GPCR Heterodimerization: GPCRs as Allosteric Modulators
by: Karla K.V. Haack, et al.
Published: (2011)

The Use of a Non-Conventional Long-Lived Gallium Radioisotope <sup>66</sup>Ga Improves Imaging Contrast of EGFR Expression in Malignant Tumours Using DFO-ZEGFR:2377 Affibody Molecule
by: Maryam Oroujeni, et al.
Published: (2021)

Pathophysiology of GPCR Homo- and Heterodimerization: Special Emphasis on Somatostatin Receptors
by: Rishi K. Somvanshi, et al.
Published: (2012)

Imaging of fibrogenesis in the liver by [18F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β
by: Olivia Wegrzyniak, et al.
Published: (2023)

Engineering a pure and stable heterodimeric IgA for the development of multispecific therapeutics
by: Florian Heinkel, et al.
Published: (2022)

Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?
by: Natalia L. Rukavina Mikusic, et al.
Published: (2020)

Characterization of high-molecular weight by-products in the production of a trivalent bispecific 2+1 heterodimeric antibody
by: Dario A. T. Cramer, et al.
Published: (2023)

The Impact of Glycerol on an Affibody Conformation and Its Correlation to Chemical Degradation
by: Ingrid Ramm, et al.
Published: (2021)

Targeting HER2 Expressing Tumors with a Potent Drug Conjugate Based on an Albumin Binding Domain-Derived Affinity Protein
by: Javad Garousi, et al.
Published: (2021)

Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis
by: Susanne Klint, et al.
Published: (2023)

Affibody Molecules Intended for Receptor-Mediated Transcytosis via the Transferrin Receptor
by: Linnea Charlotta Hjelm, et al.
Published: (2023)

Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes in lymph nodes and reduces SHIV RNA
by: G. Pavlakis, et al.
Published: (2017)

Adjusting Heterodimeric Coiled-Coils (K/E Zipper) to Connect Autophagy-Inducing Peptide with Cell-Penetrating Peptide
by: Yoshiyuki Hakata, et al.
Published: (2023)

Computation-Aided Design of Albumin Affibody-Inserted Antibody Fragment for the Prolonged Serum Half-Life
by: Na Hyun Kwon, et al.
Published: (2022)

The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents
by: Melina Mitsiogianni, et al.
Published: (2019)

OA4-1 Heterodimeric IL-15 induces effector cell activation and trafficking to the Germinal Centers of SIV infected Macaques
by: G.N. Pavlakis, et al.
Published: (2016)

Targeted Delivery of 111In Into the Nuclei of EGFR Overexpressing Cells via Modular Nanotransporters With Anti-EGFR Affibody
by: Tatiana S. Karyagina, et al.
Published: (2020)

Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors
by: Ezio Bettini, et al.
Published: (2022)

Ultrasound-Assisted Solid-Phase Affibody Synthesis Using Z<sub>EGFR:1907</sub> as an Example-Superior to the Conventional Protocol?
by: Marie Prochiner, et al.
Published: (2024)

Targeted Bioluminescent Imaging of Pancreatic Ductal Adenocarcinoma Using Nanocarrier-Complexed EGFR-Binding Affibody-Gaussia Luciferase Fusion Protein
by: Jessica Hersh, et al.
Published: (2023)

PDGFRβ-specific affibody-directed delivery of a photosensitizer, IR700, is efficient for vascular-targeted photodynamic therapy of colorectal cancer
by: Qiuxiao Shi, et al.
Published: (2017)

Microbiological assessment of the chemo-mechanical caries removal
by: Marković Dejan, et al.
Published: (2003)

Editorial: Chemo-Radiation-Resistance in Cancer Therapy
by: Xiaoping Lin, et al.
Published: (2022)

Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer
by: Sandra Cotino-Nájera, et al.
Published: (2023)

Investigation of a neuropsychological screen for chemo-fog
by: Lea Ann Ouimet, et al.
Published: (2011)

Enzyme- and Chemo-enzyme-Catalyzed Stereodivergent Synthesis
by: Jia-Xiang Lv, et al.
Published: (2022)

Smart Nanoparticles for Chemo-Based Combinational Therapy
by: Binita Shrestha, et al.
Published: (2021)