Endogenous SIRT6 in platelets negatively regulates platelet activation and thrombosis

• Main Authors: Yanli Liu (Author), Tao Wang (Author), Qilong Zhou (Author), Guang Xin (Author), Hai Niu (Author), Fan Li (Author), Yilan Wang (Author), Shiyi Li (Author), Yuman Dong (Author), Kun Zhang (Author), Lijuan Feng (Author), Wei Fu (Author), Boli Zhang (Author), Wen Huang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Thromboembolism resulting from platelet dysfunction constitutes a significant contributor to the development of cardiovascular disease. Sirtuin 6 (SIRT6), an essential NAD+-dependent enzyme, has been linked to arterial thrombosis when absent in endothelial cells. In the present study, we have confir...