Survival of HT29 Cancer Cells Is Affected by IGF1R Inhibition via Modulation of Self-DNA-Triggered TLR9 Signaling and the Autophagy Response

Survival of HT29 Cancer Cells Is Affected by IGF1R Inhibition via Modulation of Self-DNA-Triggered TLR9 Signaling and the Autophagy Response

Purpose: In HT29 colon cancer cells, a close interplay between self-DNA-induced TLR9 signaling and autophagy response was found, with remarkable effects on cell survival and differentiation. IGF1R activation drives the development and malignant progression of colorectal cancer. IGF1R inhibition disp...

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Main Authors: Ferenc Sipos (Author), Bettina Bohusné Barta (Author), Ágnes Simon (Author), Lőrinc Nagy (Author), Titanilla Dankó (Author), Regina Eszter Raffay (Author), Gábor Petővári (Author), Viktória Zsiros (Author), Barnabás Wichmann (Author), Anna Sebestyén (Author), Györgyi Műzes (Author)
Format: Book
Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
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