Hepatotoxic metabolites in Polygoni Multiflori Radix- Comparative toxicology in mice

• Main Authors: Shixiao Wang (Author), Xiang Kong (Author), Ning Chen (Author), Pengwei Hu (Author), Hamza Boucetta (Author), Zhaoliang Hu (Author), Xin Xu (Author), Pei Zhang (Author), Xiang Zhan (Author), Ming Chang (Author), Rui Cheng (Author), Wei Wu (Author), Min Song (Author), Yuting Lu (Author), Taijun Hang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polygoni Multiflori Radix (PM) and Rhei radix et rhizoma (rhubarb) contain similar hepatocyte-toxic anthraquinones such as emodin (major free anthraquinone in PM), physcion and their glycosides. In clinical practice, PM hepatotoxicity has been widely reported, although rhubarb is not recognized as h...