A β-Cyclodextrin-Based Nanoparticle with Very High Transfection Efficiency Unveils siRNA-Activated TLR3 Responses in Human Prostate Cancer Cells

• Main Authors: Cristina de la Torre (Author), Pablo Játiva (Author), Inmaculada Posadas (Author), Darío Manzanares (Author), José L. Jiménez Blanco (Author), Carmen Ortiz Mellet (Author), José Manuel García Fernández (Author), Valentín Ceña (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Synthetic double-stranded small interfering RNAs (siRNAs) mimic interference RNAs (RNAi) and can bind target mRNAs with a high degree of specificity, leading to selective knockdown of the proteins they encode. However, siRNAs are very labile and must be both protected and transported by nanoparticle...