Three-Dimensional Analysis of Sex- and Gonadal Status- Dependent Microglial Activation in a Mouse Model of Parkinson's Disease

• Main Authors: Amandine Isenbrandt (Author), Katherine Coulombe (Author), Marc Morissette (Author), Mélanie Bourque (Author), Jérôme Lamontagne-Proulx (Author), Thérèse Di Paolo (Author), Denis Soulet (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parkinson's disease (PD) is characterized by neurodegeneration and neuroinflammation. PD prevalence and incidence are higher in men than in women and modulation of gonadal hormones could have an impact on the disease course. This was investigated in male and female gonadectomized (GDX) and SHAM...