Chlorzoxazone reduced the paracetamol-induced toxicity via competitive inhibition of CYP2E1-mediated metabolism

• Main Authors: Ravindra Babu Pingili (Author), Sridhar Vemulapalli (Author), Manideep V. V. N. Gadamsetty (Author), Divya Presingu (Author), Ruthvik Katuri (Author), Vijayalakshmi Rachamsetty (Author), Naveen Babu Kilaru (Author)
• Format: Book
• Published: SpringerOpen, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Drug metabolism is crucial to attaining the therapeutic index of any drug. The metabolism and elimination of the drugs are governed mainly by P-glycoprotein (P-gp) and Cytochrome P450 (CYP). Paracetamol is mostly used as analgesic and antipyretic agent. The metabolism of paraceta...