AMPK-Dependent YAP Inhibition Mediates the Protective Effect of Metformin against Obesity-Associated Endothelial Dysfunction and Inflammation

• Main Authors: Lijing Kang (Author), Juanjuan Yi (Author), Chi-Wai Lau (Author), Lei He (Author), Qinghua Chen (Author), Suowen Xu (Author), Jun Li (Author), Yin Xia (Author), Yuanting Zhang (Author), Yu Huang (Author), Li Wang (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hyperglycemia is a crucial risk factor for cardiovascular diseases. Chronic inflammation is a central characteristic of obesity, leading to many of its complications. Recent studies have shown that high glucose activates Yes-associated protein 1 (YAP) by suppressing AMPK activity in breast cancer ce...