Cathepsin S Cleaves BAX as a Novel and Therapeutically Important Regulatory Mechanism for Apoptosis

• Main Authors: Surinder M. Soond (Author), Lyudmila V. Savvateeva (Author), Vladimir A. Makarov (Author), Neonila V. Gorokhovets (Author), Paul A. Townsend (Author), Andrey A. Zamyatnin (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Certain lysosomal cathepsin proteins have come into focus as being good candidates for therapeutic targeting, based on them being over-expressed in a variety of cancers and based on their regulation of the apoptotic pathway. Here, we report novel findings that highlight the ability of cathepsin S ex...