Platinum-based anticancer drugs-induced downregulation of myosin heavy chain isoforms in skeletal muscle of mouse

• Main Authors: Ken Sato (Author), Yu Miyauchi (Author), Xinran Xu (Author), Risako Kon (Author), Nobutomo Ikarashi (Author), Yoshihiko Chiba (Author), Tomoo Hosoe (Author), Hiroyasu Sakai (Author)
• Format: Book
• Published: Elsevier, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cisplatin, a platinum-based anticancer drug used frequently in cancer treatment, causes skeletal muscle atrophy. It was predicted that the proteolytic pathway is enhanced as the mechanism of this atrophy. Therefore, we investigated whether a platinum-based anticancer drug affects the expression of t...